HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Fluorobenzyl)malonic acid → 3-(4-Fluorophenyl)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Fluorobenzyl)malonic acid | HCID 15120643 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-(4-Fluorophenyl)propionic acid | HCID 136302 | — |
Reaction Steps
The 4-fluorobenzylmalonic acid is heated to 170° to 175° C. for 1.5 hours. After cooling, the reaction product is stirred with a little diethyl ether. 41.6 of 3-(4-fluorophenyl)propionic acid of m.p. 85° to 88° C. [from ethyl acetate/petroleum ether (1:4)] thereby crystallize out.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04337267 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-e392486c2a3e43da9c860dcce3a5dade |
| Source note | uspto-grants-1982_06 |