HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 12851862, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(4-Bromophenyl)isoquinoline-5-acetonitrile | HCID 12851834 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 12851862 | HCID 12851862 | — |
Reaction Steps
A mixture of 7.5 g of 1-(4-bromophenyl)isoquinoline-5-acetonitrile, 70 ml of acetic acid and 35 ml of 50% sulfuric acid was heated with stirring for 3 hours. After the reaction, water was added, and the pH of the reaction mixture was adjusted to 2 with an aqueous solution of sodium hydroxide. The crystals that precipitated were collected by filtration, and recrystallized from tetrahydrofuran-acetone to afford 7.0 g of 1-(4-bromophenyl)isoquinoline-5-acetic acid having a melting point of 230.5° to 232.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04337256 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-97039894d1a541a784e6d002945d4c1c |
| Source note | uspto-grants-1982_06 |