HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxide (P4O10) → 1-(4-Fluorophenyl)-5-methyl-3,4-dihydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxide (P4O10) | HCID 14812 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-(4-Fluorobenzoylamino)-2-(2-methylphenyl)ethane | HCID 12851810 | — |
| Product | 1-(4-Fluorophenyl)-5-methyl-3,4-dihydroisoquinoline | HCID 12851822 | — |
Reaction Steps
1-(4-Fluorobenzoylamino)-2-(2-methylphenyl)-ethane, phosphorus oxychloride and phosphorus pentoxide were reacted in the same way as in step (b) of Example 1 to afford 1-(4-fluorophenyl)-5-methyl-3,4-dihydroisoquinoline as colorless prisms having a melting point of 71.0 to 71.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04337256 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-6fca38ba2e984a4a909cd344871a7f68 |
| Source note | uspto-grants-1982_06 |