Acetic Acid → HCID 12851866, compound

Participants

Reaction Steps

1-(4-Nitrophenyl)isoquinoline-5-acetonitrile (2.1 g) was dissolved in 12 ml of 75% sulfuric acid and 2 ml of acetic acid, and refluxed for 3 hours. The reaction mixture was poured into ice water, and washed with ether. The aqueous layer was neutralized with an aqueous solution of sodium hydroxide. The crystals that precipitated were collected by filtration, and recrystallized from tetrahydrofuran to afford 2.1 g of 1-(4-nitrophenyl)isoquinoline-5-acetic acid having a melting point of 252.2° to 253.8° C.

Provenance & Evidence