1-Isopropyl-5-dichloroacetylaminomethylisoquinoline → 1-Isopropyl-5-aminomethylisoquinoline

Participants

Reaction Steps

Twenty grams of 1-isopropyl-5-dichloroacetylaminomethylisoquinoline was dissolved in 100 ml of conc. hydrochloric acid. The solution was heated with stirring for 1 hour. The reaction mixture was concentrated, made weakly alkaline with an aqueous solution of sodium hydroxide, and extracted with benzene to afford 8.7 g of 1-isopropyl-5-aminomethylisoquinoline as an oil.

Provenance & Evidence