HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutanecarbonyl chloride → 1-Cyclobutylcarbonylamino-2-(2-hydroxymethylphenyl)ethane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutanecarbonyl chloride | HCID 78705 | — |
| Reactant | [2-(2-Aminoethyl)phenyl]methanol | HCID 12832783 | — |
| Reactant | 1-Phenyl-5-chloro-3,4-dihydroisoquinoline | HCID 14998911 | — |
| Product | 1-Cyclobutylcarbonylamino-2-(2-hydroxymethylphenyl)ethane | HCID 20533897 | — |
Reaction Steps
1-Amino-2-(2-hydroxymethylphenyl)ethane and cyclobutanecarbonyl chloride were successively reacted in the same way as in steps (b) and (c) of Example 12 to afford 1-cyclobutylcarbonylamino-2-(2-hydroxymethylphenyl)ethane as in oil. The product was successively reacted in the same way as in steps (d), (e), (f) and (g) of Example 12 to afford 1-cyclobutylisoquinoline-5-acetonitrile. The product was treated in the same way as in Example 3 to afford 1-cyclobutylisoquinoline-5-acetic acid having a decomposition point of 202.8° to 209.8° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04337256 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-bc011fad71e2471597a421141d7cab70 |
| Source note | uspto-grants-1982_06 |