Heptanoyl chloride → 1-n-Heptanoylamino-2-(2-chlorophenyl)ethane

HRID 1156933Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:10].[C:11](Cl)(=[O:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]>>[C:11]([NH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:10])(=[O:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Participants

Reactant 2

HCID 17313Heptanoyl chloride

HCID 831172-(2-Chlorophenyl)ethylamine

Product 1

HCID 205338941-n-Heptanoylamino-2-(2-chlorophenyl)ethane

Procedure

1-Amino-2-(2-chlorophenyl)ethane and n-heptanoyl chloride were reacted in the same way as in step (a) of Example 13 to afford 1-n-heptanoylamino-2-(2-chlorophenyl)ethane as an oil. The product was successively reacted in the same way as in steps (b), (c), (d), (e), (f), (g) and (h) of Example 13 to afford 1-n-hexylisoquinoline-5-acetonitrile.

Sources & evidence

ORD record: ord-9d8c937458054a72ab4d34d86b7db023
Source dataset: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04337256

Reaction notes

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