Pivaloyl chloride → HCID 20533876, compound

HRID 1156935Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[C:11](Cl)(=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]>>[C:11]([NH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10])(=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]

Participants

Reactant 2

HCID 62493Pivaloyl chloride

HCID 20638682-Methylphenethylamine

Product 1

HCID 20533876HCID 20533876, compound

Procedure

1-Amino-2-(2-methylphenyl)ethane and pivaloyl chloride were reacted in the same way as in step (a) of Example 1 to afford 1-pivaloylamino-2-(2-methylphenyl)-ethane. The product was successively reacted in the same way as in steps (b), (c), (d) and (e) of Example 1 to afford 1-tert-butylsioquinoline-5-acetonitrile.

Sources & evidence

ORD record: ord-2c1ae988de6c4476957b16948696cd41
Source dataset: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04337256

Reaction notes

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