HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)benzoyl chloride → 1-(4-Trifluoromethylbenzoyl)amino-2-(2-hydroxymethylphenyl)ethane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)benzoyl chloride | HCID 67607 | — |
| Reactant | [2-(2-Aminoethyl)phenyl]methanol | HCID 12832783 | — |
| Reactant | 1-Phenyl-5-chloro-3,4-dihydroisoquinoline | HCID 14998911 | — |
| Product | 1-(4-Trifluoromethylbenzoyl)amino-2-(2-hydroxymethylphenyl)ethane | HCID 20533940 | — |
Reaction Steps
1-Amino-2-(2-hydroxymethylphenyl)ethane and 4-trifluoromethylbenzoyl chloride were successively reacted in the same way as in steps (b) and (c) of Example 12 to afford 1-(4-trifluoromethylbenzoyl)amino-2-(2-hydroxymethylphenyl)ethane having a melting point of 145.8° to 146.3° C. The product was successively reacted in the same way as in steps (d), (e), (f) and (g) of Example 12 to afford 1-(4-trifluoromethylphenyl)isoquinoline-5-acetonitrile having a melting point of 121.9° to 122.6° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04337256 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-a53695eb2630469c9971dede5b8774a2 |
| Source note | uspto-grants-1982_06 |