Methylamine → HCID 12851856, compound

Participants

Reaction Steps

Ethyl 1-isopropylisoquinoline-5-acetate (0.4 g) was dissolved in 20 ml of ethanol, and 5 ml of a 40% aqueous solution of monomethylamine was added. The mixture was stirred under heat for 12 hours. After the reaction, the solvent was distilled off. The residue was extracted with benzene, washed in water, and dried. The solvent was distilled off under reduced pressure. Recrystallization from benzenecyclohexane afforded 0.15 g of 1-isopropylisoquinoline-5-acetic acid methylamide as colorless needles having a melting point of 153.2° to 153.7° C.

Provenance & Evidence