2-Methylbenzoyl chloride → HCID 20533874, compound

HRID 1156939Notes

Reaction equation

HRID 1156939 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:10].[C:11]1([CH3:20])[C:12]([C:17](Cl)=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=1>>[C:11]1([CH3:20])[C:12]([C:17]([NH:1][CH2:2][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[Cl:10])=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 702762-Methylbenzoyl chlorideHCID 831172-(2-Chlorophenyl)ethylamine

Product 1

HCID 20533874HCID 20533874, compound

Procedure

1-Amino-2-(2-chlorophenyl)ethane and o-toluoyl chloride were reacted in the same way as in step (a) of Example 13 to afford 1-(o-toluoylamino)-2-(2-chlorophenyl)ethane having a melting point of 91.6° C. The product was successively reacted in the same way as in steps (b), (c), (d), (e), (f), (g), and (h) of Example 13 to afford 1-(2-methylphenyl)isoquinoline-5-acetonitrile having a melting point of 120.3° to 120.4° C.

Sources & evidence

ORD record
ord-5cf29aefa01e4b609543978adea96f3c
Source dataset
uspto-grants-1982_06
Patent number
US04337256

Reaction notes

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