HCID 86737844, compound → HCID 12884446, compound

Participants

Reaction Steps

Following the procedure set forth in Example 49, 4a-(3-methoxyphenyl)-2-methyl-3,4,4a5,6,7-hexahydro-2-pyrindine was hydrogenated over platinum oxide to provide a 60:40 mixture of trans-4a-(3-methoxyphenyl)-2-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-2-pyrindine and the corresponding cis-isomer. The trans isomer was crystallized as the picrate salt. The cis isomer was isolated as the free base, namely cis-4a-(3-methoxyphenyl)-2-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-2-pyrindine. M.P. 40°-43° C.

Provenance & Evidence