反应详情

温度

25 °C

2-Amino-3-chlorothiophenol (1.6 g) and pyridine (0.8 g) were dissolved in benzene (20 ml), and chloroacetyl chloride (1.2 g) was gradually added dropwise thereto at room temperature (25° C.) with stirring. After the addition was finished, the reaction mixture was stirred at room temperature for 30 minutes, and the solvent was removed under reduced pressure. The residue obtained was washed with water, dried and recrystallized from chloroform to obtain 2.0 g of 3-chloro-2-chloroacetylaminothiophenol (m.p. 186°-187° C.).

1. additionAfter the addition
2. stirringthe reaction mixture was stirred at room temperature for 30 minutes
3. customthe solvent was removed under reduced pressure
4. customThe residue obtained
5. washwas washed with water
6. customdried
7. customrecrystallized from chloroform