HCID 54008758, compound → HCID 20534473, compound

Participants

Reaction Steps

Hydrogen was passed through a solution of 6.3 g of the acid of Step A in 100 ml of ethanol in the presence of 120 mg of platinum oxide and after the absorption of 3.86 ml of hydrogen, the mixture was filtered. The filtrate was evaporated to dryness and the 6.3 g of raw product were dissolved in 10 ml of hot isopropyl ether to which 10 ml of petroleum ether were then added. The mixture stood at room temperature, was iced and vacuum filtered. The precipitate was washed with a 1:1 isopropyl ether-petroleum ether mixture and was dried under reduced pressure to obtain 5.535 g of 9-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-nonanoic acid melting at 64° C.

Provenance & Evidence