ethyl 1-[(5,6-dichloro-9a-methyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]cyclopentane-1-carboxylate → 1-[(5,6-dichloro-9a-methyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]cyclopentane-1-carboxylic acid

HRID 1157037노트

반응식

HRID 1157037 반응식
ClC1C(Cl)=C(OCC(OCC)=O)C=C2C=1C1C(CC)(C2)CCCC=1.[Cl:25][C:26]1[C:38]([Cl:39])=[C:37]([O:40][C:41]2([C:46]([O:48]CC)=[O:47])[CH2:45][CH2:44][CH2:43][CH2:42]2)[CH:36]=[C:35]2[C:27]=1[C:28]1[C:33]([CH3:51])([CH2:34]2)[CH2:32][CH2:31][C:30](=[O:52])[CH:29]=1>>[Cl:25][C:26]1[C:38]([Cl:39])=[C:37]([O:40][C:41]2([C:46]([OH:48])=[O:47])[CH2:45][CH2:44][CH2:43][CH2:42]2)[CH:36]=[C:35]2[C:27]=1[C:28]1[C:33]([CH3:51])([CH2:34]2)[CH2:32][CH2:31][C:30](=[O:52])[CH:29]=1

참가 물질

3

반응물 2

HCID 20520807ethyl 1-[(5,6-dichloro-9a-methyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]cyclopentane-1-carboxylateHCID 57086436ethyl [(5,6-dichloro-9a-ethyl-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]acetate

생성물 1

HCID 205208691-[(5,6-dichloro-9a-methyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]cyclopentane-1-carboxylic acid

실험 절차

Carrying out a reaction as described in Example 1, Step E, except that the ethyl [(5,6-dichloro-9a-ethyl-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]acetate is replaced by an equimolar quantity of ethyl 1-[(5,6-dichloro-9a-methyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]cyclopentane-1-carboxylate, to give 1-[(5,6-dichloro-9a-methyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]cyclopentane-1-carboxylic acid.

후처리

  1. customCarrying out a reaction

출처 및 근거

ORD 기록
ord-9f37e98278bd4b20af7e4a9d7fd740ea
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337354

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