Pyridinium chloride → HCID 20520775, compound

HRID 1157043Notes

Reaction equation

HRID 1157043 reaction equation
Cl.N1C=CC=CC=1.[CH2:8]([CH:11]1[CH2:19][C:18]2[C:13](=[C:14]([Cl:23])[C:15]([Cl:22])=[C:16]([O:20]C)[CH:17]=2)[C:12]1=[O:24])[CH:9]=[CH2:10]>>[CH2:8]([CH:11]1[CH2:19][C:18]2[C:13](=[C:14]([Cl:23])[C:15]([Cl:22])=[C:16]([OH:20])[CH:17]=2)[C:12]1=[O:24])[CH:9]=[CH2:10]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 20520799HCID 20520799, compound

Product 1

HCID 20520775HCID 20520775, compound

Conditions

Temperature
195 °C

Procedure

Dry pyridine hydrochloride (500 gm.) is melted and heated to 195° C. and 2-allyl-6,7-dichloro-5-methoxy-2,3-dihydro-1H-inden-1-one (45.4 gm., 0.167 mole) is added with stirring. The reaction mixture is kept at 195° C. for 45 minutes and then poured with vigorous stirring into crushed ice (2 kg.). The crude produce is collected by filtration, washed with water and dried. The 2-allyl-6,7-dichloro-5-hydroxy-2,3-dihydro-1H-inden-1-one is recrystallized from a mixture of ethanol andwater.

Workup

  1. additionpoured
  2. stirringwith vigorous stirring
  3. customThe crude produce
  4. filtrationis collected by filtration
  5. washwashed with water
  6. customdried
  7. customThe 2-allyl-6,7-dichloro-5-hydroxy-2,3-dihydro-1H-inden-1-one is recrystallized from a mixture of ethanol andwater

Sources & evidence

ORD record
ord-f98336ca52cf4f5ab9344c63df4c79e7
Source dataset
uspto-grants-1982_06
Patent number
US04337354

Reaction notes

Loading…