HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid → Acetoacetic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid | HCID 2518 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Acetoacetic Acid | HCID 96 | — |
| Product | 3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid | HCID 2518 | — |
Reaction Steps
In accordance with the above flowchart, 3,4-dihydroxycinnamic acid (1) is reacted with acetic anhydride in pyridine for 18-30 hours and then extracted with organic solvents, giving 3,4-dihydroxycinnamic acid, diacetate (2) which is further converted to the 3,4-dihydroxycinnamic acid chloride (3) by treatment with thionyl chloride in dimethylformamide at -20° to -18° C. for 30-90 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04337249 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-602d0fb017934ef19c0aecd7ceace79c |
| Source note | uspto-grants-1982_06 |