HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1157096Generated: October 31, 2026
2-Nitro-1-(prop-2-ynyl)-1H-imidazole → 3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol
https://huagongshe.com/reaction/1157096
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Nitro-1-(prop-2-ynyl)-1H-imidazole | HCID 54675143 | — |
| Reactant | 2-Azido-3-fluoropropan-1-ol | HCID 59511061 | — |
| Product | 3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol | HCID 59511063 | — |
Reaction Steps
To a vial is added alkyne 10 (1.9 g, 12.6 mmol) and 29 (1.5 g, 12.6 mmol). The solution is heated at 60° C. overnight. The material is then purified on a silica gel column using 10% MeOH:CH2Cl2 as the eluent. The material is then further purified via recrystallization using EtOAc:Hex to afford 1 as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07807394B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-e35947765d3f4c249c0172c76f00d9a5 |
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| Source note | uspto-grants-2010_10 |
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