참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrogen Peroxide | HCID 784 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-(3,4-dichlorobenzylidene)-1H-indene-1,3(2H)-dione | HCID 7514913 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-(3,4-Dichlorophenyl)-spiro (oxirane-2, 2'-indan)-1',3'-dione | HCID 11438553 | 95% |
반응 단계
To a suspension of 2-(3,4-dichloro-benzylidene)-indane-1,3-dione (1c) (1.6 g, 5.2 mmol) in MeOH (13 mL) was added hydrogen peroxide (30% solution, 3 mL). The mixture was cooled to 0° C. and sodium hydroxide (1N, 300 μL) was added dropwise. After addition was completed, stirring was continued at room temperature for 1 h. The mixture was then poured into water (5 mL) and the resulting solid was collected by filtration and washed with water and MeOH. After drying under high vacuum 3-(3,4-dichlorophenyl)-spiro (oxirane-2,2′-indan)-1′,3′-dione (Id) (1.6 g, 95% yield) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07807670B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_10 |
|---|
| ORD ID | ord-50a816043c234ac5ac0459bb46a23285 |
|---|
| 출처 메모 | uspto-grants-2010_10 |
|---|
