HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → (S)-(+)-2-Hydroxypropyl P-toluenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (S)-propane-1,2-diol | HCID 439846 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-(+)-2-Hydroxypropyl P-toluenesulfonate | HCID 10955373 | — |
Reaction Conditions
| Temperature | -20 °C |
|---|
Reaction Steps
Triethylamine was added to methylene chloride solution of (2S)-propane-1,2-diol, and then methylene chloride solution of p-toluenesulfonyl chloride was added thereto at −20° C. and stirred at room temperature for 18 hours to obtain (2S)-2-hydroxypropyl-4-methylbenzene sulfonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807664B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-82590563649f43568c05c80061f7287a |
| Source note | uspto-grants-2010_10 |