HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)-4-(benzyloxy)nitrobenzene → 4-Amino-2-(trifluoromethyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)-4-(benzyloxy)nitrobenzene | HCID 21952084 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Amino-2-(trifluoromethyl)phenol | HCID 22060572 | 90% |
Reaction Steps
To the suspension of 1-benzyloxy-4-nitro-2-trifluoromethylbenzene (575 mg, 1.96 mmol) in methanol was added catalytic amount of 5% palladium on carbon under a hydrogen atmosphere. The mixture was stirred for 4 hrs and filter through celite. The filtrate was concentrated to afford 4-amino-2-trifluoromethylphenol (311 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807672B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-a62629dac61d4946976b43a4615c4765 |
| Source note | uspto-grants-2010_10 |