HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron Trichloride → 4-Amino-2-bromophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron Trichloride | HCID 25135 | — |
| Reactant | 4-Benzyloxy-3-bromophenylamine | HCID 22017737 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Amino-2-bromophenol | HCID 14440265 | 56% |
Reaction Steps
To a solution of 4-amino-1-benzyloxy-2-bromobenzene in 2 mL of dichloromethane at −78 C was added boron trichloride (0.4 mL, 1 M in DCM) dropwise. The reaction was quenched with water at 0 C, concentrated and dried under vacuum to afford 4-amino-2-bromo-1-hydroxybenzene (17 mg, 56% two steps)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807672B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-3ae0cd9993264b1a84990d5f8de9d37e |
| Source note | uspto-grants-2010_10 |