Cesium fluoride → 4-(4-Pyrimidin-2-yl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Cesium fluoride	HCID 25953	—
반응물	2-(Tributylstannyl)pyrimidine	HCID 2763251	—
반응물	1-N-Boc-4-(4-bromophenyl)piperidine	HCID 27281782	—
촉매	Di-t-butylphosphine palladium	HCID 86614436	—
생성물	4-(4-Pyrimidin-2-yl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester	HCID 59511342	—

반응 조건

온도	90 °C

반응 단계

A mixture containing 4-(4-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (100 mg, 0.29 mmol), 2-tributylstannanyl-pyrimidine (130 mg, 0.36 mmol), cesium fluoride (85 mg, 0.56 mmol) and palladium di-tert-butylphosphine was degassed three times with Ar. Dioxane was added and the formed reaction mixture was stirred at 90° C. overnight under Ar. Then the reaction mixture was filter through celite and the solvent was removed under vacuum and crude product was used directly in the next step.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07807672B2
출처 데이터셋	uspto-grants-2010_10
ORD ID	ord-333b1232f1e24d4cbf5a0e9d3edbb3f1
출처 메모	uspto-grants-2010_10