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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1157176Generated: November 4, 2026

Trifluoroacetic acid → 2-Piperidin-4-ylethynyl-pyrimidine

https://huagongshe.com/reaction/1157176

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-Pyrimidin-2-ylethynyl-piperidine-1-carboxylic acid tert-butyl esterHCID 66939877—
Product2-Piperidin-4-ylethynyl-pyrimidineHCID 59511345—

Reaction Steps

4-Pyrimidin-2-ylethynyl-piperidine-1-carboxylic acid tert-butyl ester was treated with TFA for 10 minutes and concentrated, lyophilized to provide the title product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07807672B2
Source datasetuspto-grants-2010_10
ORD IDord-50c63af0e9b64b18ba7edfa48a6aaf77
Source noteuspto-grants-2010_10