HCID 68426021, compound → HCID 68425214, compound

HRID 1157187Notes

Reaction equation

HRID 1157187 reaction equation
C([O:5][C:6](=[O:24])[CH2:7][N:8]1[CH2:12][CH2:11][CH:10]([C:13](=[O:23])[NH:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([Cl:22])[CH:16]=2)[CH2:9]1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Cl:22][C:17]1[CH:16]=[C:15]([NH:14][C:13]([CH:10]2[CH2:11][CH2:12][N:8]([CH2:7][C:6]([OH:24])=[O:5])[CH2:9]2)=[O:23])[CH:20]=[CH:19][C:18]=1[OH:21]

Participants

3

Reactant 1

HCID 68426021HCID 68426021, compound

Product 1

HCID 68425214HCID 68425214, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

[3-(3-Chloro-4-hydroxy-phenylcarbamoyl)-pyrrolidin-1-yl]-acetic acid tert-butyl ester was dissolved in TFA/DCM (90:10) solution. After stirring at RT for 30 min, the reaction mixture was concentrated and acetonitrile/water (10 ml, 3:1) was added. After removal of solvent, the residue was purified using Prep-HPLC to give 450 mg of product.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. additionacetonitrile/water (10 ml, 3:1) was added
  3. customAfter removal of solvent
  4. customthe residue was purified

Sources & evidence

ORD record
ord-e5c385defd5548bba482818f923ded54
Source dataset
uspto-grants-2010_10
Patent number
US07807672B2

Reaction notes

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