反应详情

[3-(3-Chloro-4-hydroxy-phenylcarbamoyl)-pyrrolidin-1-yl]-acetic acid tert-butyl ester was dissolved in TFA/DCM (90:10) solution. After stirring at RT for 30 min, the reaction mixture was concentrated and acetonitrile/water (10 ml, 3:1) was added. After removal of solvent, the residue was purified using Prep-HPLC to give 450 mg of product.

1. concentrationthe reaction mixture was concentrated
2. additionacetonitrile/water (10 ml, 3:1) was added
3. customAfter removal of solvent
4. customthe residue was purified