Dimethylamine → HCID 178483750, compound

HRID 1157295Notes

Reaction equation

HRID 1157295 reaction equation
Cl[CH2:2][CH2:3][NH:4][C:5]1[CH:9]=[CH:8][NH:7][N:6]=1.[CH3:10][NH:11][CH3:12]>CO>[CH3:10][N:11]([CH3:12])[CH2:2][CH2:3][NH:4][C:5]1[CH:9]=[CH:8][NH:7][N:6]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 178478496HCID 178478496, compound

Product 1

HCID 178483750HCID 178483750, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

In a sealable flask, the N-(2-chloroethyl)-1H-pyrazol-3-amine (0.214 g, 1.47 mmol) were combined with 1.5 mL of dimethylamine (40% in H2O). The mixture flask was sealed, and the mixture was heated to 100° C. for 16 h. The mixture was cooled to rt, and transferred to a rb flask with MeOH. The solvent was removed under reduced pressure to give the N1,N1-dimethyl-N2-(1H-pyrazol-3-yl)ethane-1,2-diamine in quantitative yield. LCMS: m/e 155.3 (M+H)+, ret time 0.96 min (method 3).

Workup

  1. customThe mixture flask was sealed
  2. temperatureThe mixture was cooled to rt
  3. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-76d6effcff354ae09cf9814d726f2c22
Source dataset
uspto-grants-2010_10
Patent number
US07807671B2

Reaction notes

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