1H-Tetrazole, 5-chloro-1-phenyl- → HCID 24874670, compound

Participants

Reaction Steps

(3R,5S)-3,5-dimethyl-1-(1-phenyl-1H-tetrazol-5-yl)piperazine was prepared via method A in chemistry section 1 using (2R,6S)-2,6-dimethylpiperazine and 5-chloro-1-phenyl-1H-tetrazole. (3R,5S)-3,5-dimethyl-1-(1-phenyl-1H-tetrazol-5-yl)piperazine was coupled with 2-(4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid using method B for the preparation of compound 3 in chemistry section A to provide the desired product 1-((2R,6S)-2,6-dimethyl-4-(1-phenyl-1H-tetrazol-5-yl)piperazin-1-yl)-2-(4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione with the following characteristics:

Provenance & Evidence