HCID 59511218, compound → HCID 59511318, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl 4-(1-phenyl-4,5-dihydro-1H-imidazol-2-yl)piperidine-1-carboxylate (100 mg) in dry benzene (5 ml), nickel peroxide (350 mg) dissolved in dry benzene (20 ml) was added. The reaction mixture was refluxed for over-night and filtered through a celite pad using CHCl3 as eluent. The combined organic layer was removed under reduced pressure. The resulting oil was purified by column chromatography using ethyl acetate\hexane (3:7) to afford tert-butyl 4-(1-phenyl-1H-imidazol-2-yl)piperidine-1-carboxylate as pure product

Provenance & Evidence