Cyanogen Bromide → HCID 131727697, compound

Participants

Reaction Steps

TIPPS-3-amino-(L)-phenylalanine-4-ethoxycarbonylpiperazide (14.6 g; 24.9 mmol), sodium acetate (anhydrous) (5.11 g; 62.2 mmol) and cyanogen bromide (2.9 g; 27.4 mmol) were dissolved in ethanol and the solution was stirred at RT for 10 h. After evaporating the solvent, the residue was taken up in ethyl acetate and the solution was extracted with 5% KHSO4, 5% NaHCO3 and distilled water. After evaporating the solvent, the crude product was purified chromatographically over silica gel.

Provenance & Evidence