Sodium hydride → HCID 16044960, compound

Participants

Reaction Steps

Solid sodium hydride (18 mg, 0.458 mmol) was added in portions to a DMF solution of 128 mg (0.458 mmol) of 3-chloro-5-(3-chloro-5-hydroxyphenoxy)benzonitrile (B-4). This was stirred for 30 minutes at room temperature and then 75 mg (0.229 mmol) of solid N-[4-(aminosulfonyl)-2-chlorophenyl]-2-bromoacetamide (A-3) was added. The reaction was then stirred at 50° C. for 14 hours until an LC/MS analysis indicated that the reaction was complete. The product was purified by a reverse phase hplc column on a Gilson unit. Clean fractions were combined and concentrated in vacuo to give the desired product 2-1 as an amorphous solid. HRMS: measured 525.9788; theoretical 525.9793. 1H NMR (DMSO-d6): 4.91 (s, 2H), 6.80 (m, 1H), 6.89 (m, 1H), 7.03 (m, 1H), 7.48 (s, 2H), 7.54 (m, 1H), 7.60 (m, 1H), 7.77 (d, 1H), 7.85 (s, 1H), 7.91 (s, 1H), 8.02 (d, 1H), 9.87 (s, 1H).

Provenance & Evidence