反应详情

In a manner similar to that described in Example 1 above for the synthesis of 1-2, from 50 mg (0.18 mmol) of 3-chloro-5-(2-chloro-5-hydroxyphenoxy)benzonitrile (C-3) and 33 mg (0.18 mmol) of 2-(chloromethyl)-1-methyl-1H-benzimidazole (31-1) was obtained the desired product 31-2 (TFA salt) as an amorphous fluffy white powder. MS M+=424. 1H NMR (CDCl3): 4.03 (s, 3H), 5.66 (s, 2H), 6.88 (d, 1H), 6.99 (m, 1H), 7.03 (dd, 1H), 7.14 (m, 1H), 7.35 (m, 1H), 7.45 (d, 1H), 7.49 (m, 3H), 7.93 (d, 1H).