Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Conditions

Reaction Steps

3-chloro-5-[2-chloro-5-({6-[(4-methoxybenzyl)amino]-1H-pyrazolo[3,4-b]pyridin-3-yl}methoxy)phenoxy]benzonitrile (37-8) was dissolved in 6 mL of TFA and heated to 60° C. for 7 hours until reaction was complete as determined by LC/MS analysis. After removal of all volatile material the crude residue was purified via prep HPLC (20%-70% acetonitrile in H2O: C18 Phenomenex Gemini) and lyophilzed from dioxane to yield the title compound in the form of a TFA salt. H1 NMR (CD3OD): 5.40 (s 2H), 6.58 (d, 1H), 6.96 (d, 1H), 7.04 (d, 1H), 7.16 (s, 1H), 7.18 (s, 1H), 7.58 (d, 1H), 7.52 (s, 1H), 8.10 (bs, 1H).

Provenance & Evidence