Iodine → HCID 178506575, compound

Participants

Reaction Steps

A solution of 1.00 g (8.40 mmol) of 1H-pyrazolo[3,4-b]pyridine in 15 mL of DMF was treated with 4.26 g (16.80 mmol) of iodine, followed by 1.77 g (31.50 mmol) of solid KOH. The resulting reddish-brown mixture was stirred at ambient temperature for 1 hour. The reaction was diluted with 5× its volume with a solution of aq. 10% NaHSO3, and the mixture stirred. The yellow solid precipitate was filtered off, washed with water, and dried in vacuo to give the desired product. The crude product was used as is in the next reaction. MS M+1=246.

Provenance & Evidence