HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-methoxy-4-methylbenzoic acid → 2-Amino-5-hydroxy-4-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-methoxy-4-methylbenzoic acid | HCID 21291497 | — |
| Solvent | Hydrogen iodide | HCID 24841 | — |
| Product | 2-Amino-5-hydroxy-4-methylbenzoic acid | HCID 58824235 | 100% |
Reaction Steps
2-Amino-5-methoxy-4-methylbenzoic acid (2.7 g, 14.9 mmol, 61%) and aqueous hydriodic acid (40%, 80 mL) were heated at reflux for 36 h. The aqueous was evaporated under vacuum and the residue washed with ether to yield 2-amino-5-hydroxy-4-methylbenzoic acid (INTERMEDIATE V.1) (2.5 g, 14.9 mmol 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807686B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-7ca3f52abfb0491b85fd4405e7dcd31b |
| Source note | uspto-grants-2010_10 |