1,4-Dioxane → HCID 59511773, compound

Participants

Reaction Steps

2-Acetylamino-5-[(S)-(+)-3-hydroxy-2-methylpropoxy]benzoic acid methyl ester (1.00 g, 3.6 mmol) prepared as in Procedure VII (Step a) was dissolved in 6 N HCl (aq.) (10 mL) and dioxane (5 mL) and heated at reflux temperature for 8 h. The mixture was then cooled and concentrated in vacuo giving 2-amino-5-[(S)-(+)-3-hydroxy-2-methylpropoxy]benzoic acid (936 mg, 3.6 mmol, 100%) as the hydrochloride salt.

Provenance & Evidence