Potassium Carbonate → HCID 59511789, compound

Participants

Reaction Conditions

Reaction Steps

To trifluoromethanesulfonic acid 3-[(cyclopropylmethylcarbamoyl)methyl]-4-oxo-2-phenyl-3,4-dihydroquinazolin-6-yl ester (100 mg, 0.2 mmol) in acetone (2 mL) and water (1 mL) was added 3-hydroxyphenyl boronic acid (60 mg, 0.4 mmol), K2CO3 (excess), and tetrakis(triphenylphosphine)palladium (23 mg, 10 mol %). The solution was heated at 60° C. for 1 h. The resulting mixture was cooled to room temperature and the solid material collected by filtration, washed with acetone and dried in vacuo to give N-cyclopropylmethyl-2-[6-(3-hydroxymethylphenyl)-4-oxo-2-phenyl-4H-quinazolin-3-yl]acetamide (60 mg, 0.14 mmol, 68%).

Provenance & Evidence