HCID 68523091, compound → HCID 59511763, compound

Participants

Reaction Steps

A solution of N-tert-butyl-2-[2-(3-chlorophenyl)-4-oxo-6-(4-pyrrolidin-1-ylbut-1-enyl)-4H-quinazolin-3-yl]acetamide (EXAMPLE 10a) (303 mg, 0.62 mmol) in dry methanol (6 mL) was sparged (5 min) with argon, and 10% Pd/C (24 mg, catalytic) was added. The reaction mixture was stirred under a hydrogen atmosphere(1 atm.) for 4 h at room temperature. The mixture was filtered through CELITE™, and the filter cake was washed with methanol (3×10 mL). The filtrates were evaporated under reduced pressure to afford N-tert-butyl-2-[2-(3-chlorophenyl)-4-oxo-6-(4-pyrrolidin-1-ylbutyl)-4H-quinazolin-3-yl]acetamide (EXAMPLE 11a) (223 mg, 0.45 mmol, 73%) as yellow foam.

Provenance & Evidence