HCID 59511752, compound → HCID 59511754, compound

Participants

Reaction Steps

To a solution of N-isopropyl-2-[6-[(4-methoxybenzyl)-(3-piperidin-1-ylpropyl)amino]-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]acetamide (EXAMPLE 3r) (44 mg, 0.07 mmol) in ethanol (7 mL) was added 10% Pd/C (−25 mg, catalytic). The mixture was stirred under an atmosphere of hydrogen (50 p.s.i.) for 18 h. The mixture was filtered through CELITE™ and concentrated in vacuo. The resulting oil was purified by chromatography on a silica gel with methanol:dichloromethane (1:9, v/v) as eluent. The resultant yellow solid was further purified using preparatory HPLC to yield N-isopropyl-2-[2-(3-methoxyphenyl)-4-oxo-6-(3-piperidin-1-ylpropylamino)-4H-quinazolin-3-yl]acetamide (EXAMPLE 13a) (9 mg, 0.02 mmol, 24%) as a yellow solid.

Provenance & Evidence