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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1157497Generated: November 4, 2026

ethyl (S)-2-amino-3-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}propionate → methyl (R)-2-amino-3-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}propionate

https://huagongshe.com/reaction/1157497

Reaction equation

Participants

RoleNameHCIDCharge
Reactantethyl (S)-2-amino-3-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}propionateHCID 69685681—
Reactantmethyl (R)-3-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}-2-tert-butoxycarbonylaminopropionateHCID 69686257—
Productmethyl (R)-2-amino-3-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}propionateHCID 6968625192%

Reaction Steps

In a manner similar to the preparation of ethyl (S)-2-amino-3-{3′-[(benzoylmethylamino)methyl]biphenyl-4-yl}propionate (Example 28f), using 5.6 g of methyl (R)-3-{3′-[(benzoylmethylamino)methyl]biphenyl-4-yl}-2-tert-butoxycarbonylaminopropionate, 4.1 g of amine are obtained with a 92% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07807669B2
Source datasetuspto-grants-2010_10
ORD IDord-94252264e64d4298b2e1e938eca0a7b2
Source noteuspto-grants-2010_10