2,5-Difluorophenylacetic acid → 2-(2,5-Difluorophenyl)-N-(3-{3-[2-(phenylamino)-4-pyrimidinyl]pyrazolo[1,5-a]pyridin-2-yl}phenyl)acetamide

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Reaction Steps

The title compound was synthesized from 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-phenyl-2-pyrimidine (see Example 3, Step H) and (2,5-difluorophenyl)acetic acid using the coupling conditions described in Example 5. 1H NMR (400 MHz, DMSO-d6): δ 3.76 (s, 2H), 6.53 (d, 1H, J=5.3 Hz), 6.94 (m, 1H), 7.10-7.27 (m, 7H), 7.41-7.48 (m, 2H), 7.69-7.76 (m, 3H), 7.89 (m, 1H), 8.27 (d, 1H, J=5.3 Hz), 8.48 (m, 1H), 8.83 (m, 1H), 9.56 (s, 1H), 10.39 (s, 1H). ES-LC/MS m/z=533 [M+H]+.

Provenance & Evidence