HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-amino-N,N-dimethylbenzylamine → 2-Phenyl-N-(3-{3-[2-(phenylamino)-4-pyrimidinyl]pyrazolo[1,5-a]pyridin-2-yl}phenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-amino-N,N-dimethylbenzylamine | HCID 99294 | — |
| Reactant | N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,2,2-trifluoroacetamide | HCID 59513717 | — |
| Product | 2-Phenyl-N-(3-{3-[2-(phenylamino)-4-pyrimidinyl]pyrazolo[1,5-a]pyridin-2-yl}phenyl)acetamide | HCID 57737256 | 78% |
Reaction Steps
The title compound was prepared from N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,2,2-trifluoroacetamide (see Example 1, Step C) and 3-(dimethylaminomethyl)aniline using displacement conditions described in Example 1, Step D to generate the product in 78% yield. ES-LC/MS m/z=532 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807673B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-25fad6113fb1450bb271be1f76b01a48 |
| Source note | uspto-grants-2010_10 |