2-Thiopheneacetyl chloride → HCID 57737224, compound

Participants

Reaction Steps

The title compound was prepared from 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-{3-[(dimethylamino)methyl]phenyl}-2-pyrimidinamine and 2-thiopheneacetyl chloride using acylation conditions described in Example 1, Step F to generate the product in 88% yield. 1H NMR (400 MHz, DMSO-d6): δ 2.11 (s, 6H), 3.26 (s, 2H), 3.86 (s, 2H), 6.46 (d, 1H, J=5.3 Hz), 6.85 (d, 1H, J=7.5 Hz), 6.96 (m, 2H), 7.10-7.19 (m, 2H), 7.26 (d, 1H, J=7.9 Hz), 7.36-7.48 (m, 3H), 7.62 (d, 1H, J=8.2 Hz), 7.69 (s, 1H), 7.73 (d, 1H, J=9.1 Hz), 7.89 (s, 1H), 8.23 (d, 1H, J=5.3 Hz), 8.51 (d, 1H, J=8.8 Hz), 8.82 (d, 1H, J=6.9 Hz), 9.52 (s, 1H), 10.35 (s, 1H); ES-LC/MS m/z=560 [M+H]+.

Provenance & Evidence