Pyrrolidine → HCID 59511429, compound

Participants

Reaction Conditions

Reaction Steps

N-(3-{3-[2-({3-[(2-Chloroethyl)oxy]phenyl}amino)-4-pyrimidinyl]pyrazolo[1,5-a]pyridin-2-yl}phenyl)-2,2,2-trifluoroacetamide (0.5 g, 0.85 mmol) was dissolved in pyrrolidine and heated to 50° C. for 18 h. Upon completion the reaction was then cooled and absorbed directly onto silica gel. Purification via column chromatography using a 0-20% gradient of EtOAc/MeOH w/NH4OH afforded the desired product as a yellow solid, 310 mg, 74% yield. ES-LC/MS m/z 492 [M+H]+.

Provenance & Evidence