2-Thiopheneacetyl chloride → HCID 57737196, compound

Participants

Reaction Steps

The title compound was synthesized from 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-{[3-(dimethylamino)propyl]oxy}phenyl)-2-pyrimidinamine using acylation with 2-thienylacetyl chloride as described in Example 10, Step E to yield a light brown solid in 48% yield. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.8 (s, 2H) 2.1 (s, 6H) 2.3 (s, 2H) 3.9 (s, 2H) 3.9 (d, J=6.2 Hz, 2H) 6.5 (m, 2H) 7.0 (m, 2H) 7.1 (m, 2H) 7.3 (s, 2H) 7.4 (m, 2H) 7.5 (m, 2H) 7.7 (m, 1H) 7.9 (d, J=2.2 Hz, 1H) 8.2 (d, J=5.3 Hz, 1H) 8.5 (s, 1H) 8.8 (d, J=7.0 Hz, 1H) 9.5 (s, 1H) 10.3 (s, 1H). ES-LC/MS m/z 604 [M+H]+.

Provenance & Evidence