2-Thiopheneacetyl chloride → HCID 57737187, compound

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Reaction Steps

The title compound was synthesized from 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-{[2-(diethylamino)ethyl]oxy}phenyl)-2-pyrimidinamine using acylation with 2-thienylacetyl chloride as described in Example 10, Step E to yield a light brown solid in 57% yield. 1H NMR (400 MHz, DMSO-D6) δ ppm 2.8 (s, 5H) 3.8 (d, J=0.9 Hz, 3H) 3.9 (s, 1H) 4.2 (s, 1H) 6.5 (d, J=5.3 Hz, 1H) 6.6 (s, 1H) 6.9 (m, 6H) 7.1 (s, 3H) 7.2 (s, 1H) 7.4 (m, 1H) 7.6 (s, 1H) 7.7 (s, 1H) 7.9 (s, 1H) 8.2 (d, J=5.5 Hz, 1H) 8.5 (s, 1H) 8.8 (m, 1H) 9.6 (s, 1H) 10.4 (s, 1H). ES-LC/MS m/z 590 [M+H]+.

Provenance & Evidence