2-Thiopheneacetyl chloride → HCID 57737184, compound

Participants

Reaction Steps

The title compound was prepared from {4-[2-(3-amino-4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinyl}[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amine and 2-thiopheneacetyl chloride using acylation conditions described in Example 36, Step H to generate the desired product in 76% yield. 1H NMR (400 MHz, d6-DMSO) δ 10.14 (s, 1H), 9.42 (s, 1H), 8.83 (d, J=6.9 Hz, 1H), 8.42 (d, J=8.7 Hz, 1H), 8.29 (d, J=6.6 Hz, 1H), 8.25 (d, J=5.4 Hz, 1H), 7.61 (s, 1H), 7.35-7.47 (m, 5H), 7.03-7.13 (m, 4H), 6.52 (d, J=5.4 Hz, 1H), 3.99 (s, 2H), 2.87-2.99 (m, 3H), 2.66-2.72 (m, 2H), 2.21 (s, 6H). ES-LC/MS m/z=604 [M+H]+.

Provenance & Evidence