HRID1157597

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17756182

未命名化合物

结构：O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Cl)n2)c1)C(F)(F)F

HCID59513717

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc(Cl)c(OCCCl)c3)n2)c1)C(F)(F)F

HCID57737180

未命名化合物

收率 34%

PROCEDURE

实验过程

The compound was synthesized from N-{3-[3-(2-chloro-4-pyrimidinyl)-pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,2,2-trifluoroacetamide (see Example 1, Step C) and 1-chloro-2-[(2-chloroethyl)oxy]-4-nitrobenzene as described in Example 10, Step C to afford a dark yellow solid in 34% yield. ES-LC/MS m/z 587 [M+H]+.

WORKUP

后处理

customto afford a dark yellow solid in 34% yield

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f79e9c0049984881b34f43ebdd1a0ca0
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07807673B2
来源说明: uspto-grants-2010_10

反应 SMILES

Cl[C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])[CH:20]=[CH:21][CH:22]=3)=[N:10][N:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)[CH:5]=[CH:4][N:3]=1.[Cl:30][C:31]1[CH:36]=[CH:35][C:34]([N+:37]([O-])=O)=[CH:33][C:32]=1[O:40][CH2:41][CH2:42][Cl:43]>>[Cl:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37][C:2]2[N:7]=[C:6]([C:8]3[C:9]([C:17]4[CH:18]=[C:19]([NH:23][C:24](=[O:29])[C:25]([F:27])([F:26])[F:28])[CH:20]=[CH:21][CH:22]=4)=[N:10][N:11]4[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=34)[CH:5]=[CH:4][N:3]=2)=[CH:33][C:32]=1[O:40][CH2:41][CH2:42][Cl:43]