2-Thiopheneacetyl chloride → HCID 57737157, compound

Participants

Reaction Steps

The title compound was synthesized from 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(4-chloro-3-{[2-(dimethylamino)ethyl]oxy}phenyl)-2-pyrimidinamine using 2-thienylacetyl chloride as described in Example 10, Step E to give a yellow solid in 70% yield. 1H NMR (300 MHz, DMSO-D6) δ ppm 2.2 (s, 6H) 2.6 (t, J=5.8 Hz, 2H) 3.9 (s, 2H) 4.0 (t, J=6.0 Hz, 2H) 6.6 (d, J=5.2 Hz, 1H) 7.0 (d, J=4.2 Hz, 2H) 7.2 (m, 1H) 7.3 (m, 1H) 7.4 (m, 2H) 7.5 (s, 1H) 7.6 (s, 1H) 7.8 (m, 2H) 7.9 (s, 1H) 8.3 (d, J=5.2 Hz, 1H) 8.5 (d, J=9.7 Hz, 1H) 8.9 (d, J=6.7 Hz, 2H) 9.7 (s, 1H) 10.4 (s, 1H). ES-LC/MS m/z 624 [M+H]+.

Provenance & Evidence