HCID 59511390, compound → HCID 57737183, compound

HRID 1157605Notes

Reaction equation

HRID 1157605 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])[CH:20]=[CH:21][CH:22]=3)=[N:10][N:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)[CH:5]=[CH:4][N:3]=1.[CH3:30][O:31][C:32]1[CH:38]=[CH:37][C:35]([NH2:36])=[CH:34][C:33]=1[N:39]1[CH2:44][CH2:43][N:42]([CH2:45][CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH2:41][CH2:40]1>>[F:26][C:25]([F:28])([F:27])[C:24]([NH:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:9]2[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH:36][C:35]4[CH:37]=[CH:38][C:32]([O:31][CH3:30])=[C:33]([N:39]5[CH2:44][CH2:43][N:42]([CH2:45][CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH2:41][CH2:40]5)[CH:34]=4)[N:7]=3)=[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][N:11]3[N:10]=2)[CH:18]=1)=[O:29]

Participants

3

Reactant 2

HCID 59511390HCID 59511390, compoundHCID 59513717N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,2,2-trifluoroacetamide

Product 1

HCID 57737183HCID 57737183, compoundYield 42%

Procedure

The compound was synthesized from N-{3-[3-(2-chloro-4-pyrimidinyl)-pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,2,2-trifluoroacetamide (see Example 1, Step C) and 4-(methyloxy)-3-{4-[2-(methylsulfonyl)ethyl]-1-piperazinyl}aniline to afford a yellow solid in 42% yield. ES-LC/MS m/z 695 [M+H]+.

Workup

  1. customto afford a yellow solid in 42% yield

Sources & evidence

ORD record
ord-afc01c3aa1c74d1a877eab4eca6f312d
Source dataset
uspto-grants-2010_10
Patent number
US07807673B2

Reaction notes

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