N-(2,3-Dihydro-5-nitro-1H-inden-2-yl)-2,2,2-trifluoroacetamide → N-(5-amino-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

Beteiligte Stoffe

Reaktionsschritte

2,2,2-Trifluoro-N-(5-nitro-2,3-dihydro-1H-inden-2-yl)acetamide (245 mg, 0.89 mmol) was dissolved in EtOAc and stirred vigorously for 15 h. with 5% Pd/C (70 mg) under hydrogen atmosphere (1 atm). The reaction was filtered through celite and the solvent was removed under vacuum. Filtration yielded 214 mg (98%) of the desired amine as a brown powder. 1H NMR (400 MHz, DMSO-d6) δ 9.60 (d, J=7.1 Hz, 1H), 6.81 (d, J=8.0 Hz, 1H), 6.39 (s, 1H), 6.34 (d, J=8.1 Hz, 1H), 4.83 (s, 2H), 4.43 (m, 1H), 3.01 (m, 2H), 2.71 (m, 2H); ES-LC/MS (M+H)+=245.11.

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